By E. Grote, F. Bonzelius, G. Herman (auth.), K. S. Kosik M.D., D. J. Selkoe M.D., Y. Christen Ph.D. (eds.)

Like the unflinching gaze of Captain Ahab strolling the deck of the Pequod, Alzheimer researchers have had their attractions fastened firmly at the sickness for a few years. Now, as this quantity amply demonstrates, entire researchers from different fields, who've notion deeply approximately phone organic difficulties are utilising their insights to Alzheimer's disorder. The contri­ butions the following symbolize the textual content types of the complaints from the 10th "Colloque medecine et recherche" of the Fondation IPSEN dedicated to study on Alzheimer's ailment. The symposium, entitled "Alzheimer's sickness: classes from cellphone Biology" was once held in Paris on April 25, 1994. As is obvious from the various backgrounds of the participants, the clinical pursuit of Alzheimer's sickness has started to meld with extra easy disciplines, quite telephone biology. whereas at the one hand, new components of specialization are continually rising, the bounds of older disciplines are increas­ ingly blurred. probably for many of the years because the first descriptions of the affliction in 1907, the technology of Alzheimer's disorder used to be descriptive, and lay within the province of pathologists. this period of time, within which very much was once realized in regards to the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of those hallmark constructions. the fashionable period of Alzheimer's illness learn opened with the iden­ tification of the part proteins in plaques and tangles.

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J Cell Bioi 109: 3291-3302 Hunziker W, Harter C, Matter K, Mellman I (1991) Basolateral sorting in MDCK cells requires a distinct cytoplasmic domain determinant. Cell 66: 907-920 Le Bivic A, Quaroni A, Nichols B, Rodriguez-Boulan E (1990) Biogenetic pathways of plasma membrane proteins in Caco-2, a human intestinal epithelial cell line. 1 Cell Bioi 111: 1351-1361 Le Bivic A, Sambuy Y, Patzak A, Patil N, Chao M, Rodriguez-Boulan E (1991) An internal deletion in the cytoplasmic tail reverses the apical localization of human NGF receptor in transfected MDCK cells.

Enzymes involved in hydrolysis, amino acid, and sugar transport are all found on the apical plasma membrane, which, moreover, is characterized by highly differentiated microvillar outcroppings that aid in the absorption process. In contrast, the basolateral surface contained most of the membrane proteins responsible for the constitutive or "housekeeping" functions common to all cells, polarized and non-polarized (Fig. 1). Thus, the apical surface appeared to be a privileged site, transport to which whould appear most likely to require a specific sorting signal; in the absence of this signal, basolateral transport was viewed as occurring by default.

Enzymes involved in hydrolysis, amino acid, and sugar transport are all found on the apical plasma membrane, which, moreover, is characterized by highly differentiated microvillar outcroppings that aid in the absorption process. In contrast, the basolateral surface contained most of the membrane proteins responsible for the constitutive or "housekeeping" functions common to all cells, polarized and non-polarized (Fig. 1). Thus, the apical surface appeared to be a privileged site, transport to which whould appear most likely to require a specific sorting signal; in the absence of this signal, basolateral transport was viewed as occurring by default.

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