By Eleazar Shafrir, Anders A F Sima

Animal types of Diabetes: A Primer introduces features of the main generic animal species with quite a few diabetic syndromes which were built and largely investigated over the past few a long time. It contains animal versions which are available, good defined and confirmed to be of worth within the study of either kinds of diabetes. broadly referenced, this publication may be of worth to new and proven investigators, graduate scholars and pharmaceutical scientists engaged on the advance of antidiabetic and preventative modalities in numerous parts of diabetes and its problems.

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Extra info for Animal Models in Diabetes: A Primer (Frontiers in Animal Diabetes Research)

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Diabetologia, 34, 548–554. , Kastelein, R. and Bazan, F. (1996) Uncovered: the family relationship of a T-cell-membrane protein and bacterial toxins. Immunol. Today, 17, 402–405. , Chick, W. M. (1983) Passive transfer of diabetes in the BB/W rat. Science, 220, 727–728. Kolb, H. -D. (1993) IDDM: Lesson from the low-dose streptozocin model in mice. Diab. , 1, 116–126. , Rastegar, S. W. (1997) Insulin therapy of prediabetes suppresses TH1 associated gene expression in BB rat pancreas. Autoimmunity, 26, 1–6.

1995; Rigby et al, 1996). Finally, it has been observed that soluble RT6 circulates in readily detectable amounts in both BB and non-BB rats (Waite et al, 1993). 1 antibody rapidly eliminate soluble RT6 from the circulation of diabetes resistant BB rats. The existence of soluble RT6 suggests the possibility that circulating RT6 protein might possess immunomodulatory properties. MODULATION OF DIABETES EXPRESSION IN THE BB RAT The frequency and age at onset of diabetes in the spontaneously diabetic BB rat can be modified by both immunomodulatory therapeutics and by environmental perturbation.

And Wonigeit, K. (199D Diabetesprone BB rats express the RT6 alloantigen on intestinal intraepithelial lymphocytes. Eur. , 21, 2011–2015. W. (1993) International Index of Laboratory Animals, pp. 1–238. Leicester, UK: MRC Toxicology Unit, University of Leicester. , Montambault, M. B. (1990) Lactate production is the major metabolic fate of glucose in splenocytes and is altered in spontaneously diabetic BB rats. Biochem. , 272, 445–452. Fowell, D. and Mason, D. (1993) Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes.

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