By WILLIAM E PAUL

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Reinherz and his collaborators have provided evidence that the antigen can be associated with the T-cell antigen receptor through cocapping(43), coprecipitation (44), and stoichiometric coexpression(45) the two surface proteins. In addition to the T-cell receptor polypeptides, anti-T3 antibodies precipitate a major protein chain of 20 kd plus other bands of 20-28 kd (46, 47), several of which penetrate the lipid bilayer (48). The above findings support the hypothesis that T3 can act as a trigger to stimulate biochemical pathways, leading to functional changes following recognition by the antigen receptor.

Skin sensitization induced by injections of conjugates. J. Exp. Meal. 73 : 431 9. Chase, M. W. 1954. Experimental sensitization with particular reference to picryl chloride. Int. Arch. Allergy Appl. 5 : 163 10. , Smith, R. F. 1961. The specificity of allergic reactions III. Contact hypersensitivity. J. Exp. Med. 114:134 11. , Gell, P. G. H. 1959. Studies on hypersensitivity. III. The relation between delayed reactivity to the picryl group of conjugates and contact sensitivity. Immunology2 : 219 12.

3:31-58. org by HINARI on 08/27/07. For personal use only. Soluble Lytic Factors Lymphotoxinsare soluble factors found in the culture mediumof lymphoid cell lines or of lymphocytesstimulated by antigens or mitogens. They have cytostatic and/or cytolytic effects on certain cells grownin vitro, particularly the fibroblast line L-929. The possibility that lymphotoxinsare responsible for target cell damage in lytic processes of CTLand LGL requiring cell contact has long been debated, but some of the described properties of lymphotoxinshave been difficult to reconcile with this role (170).

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